Researchers sought to determine the most effective regimen of intermittent preventive treatment (IPT) against malaria for schoolchildren in the Democratic Republic of Congo. The children were given sulfadoxine/pyrimethamine (SP), SP plus piperaquine (SP/PQ), or no intervention. The SP group saw a reduction in anemia (10%), malaria parasitemia (19%), and clinical malaria (25%), while the SP/PQ group experienced an even greater reduction of 28%, 40%, and 58%, respectively. Findings suggested that SP, and even more so SP/PQ, may be a promising option for IPT in schoolchildren.
Matangila, J., et. al., International Journal of Antimicrobial Agents (January 2017).