Long known to reduce child mortality of children over six months of age, newborn vitamin A supplementation (NVAS) is being examined as a means to reduce infant mortality. NVAS involves supplementing infants shortly after birth with a single, large oral dose of VA (50,000 IU). This document guided the work of key partners in Nepal and Bangladesh who were moving forward research evidence on NVAS into programs through the development, testing and evaluation of potential delivery models at country level.